Nearly 30 Million People in England Have Avoided COVID-19: Insights on Immunity, New Variants, and Public Health


Researchers from Cambridge University have found that approximately 30 million people in England have avoided contracting COVID-19 since the pandemic began. According to their analysis, only about 51.8% of the population has been infected by February 2023, meaning nearly half of England’

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Half of England Remains COVID-Free Amid Recent Outbreak Trends

Researchers from Cambridge University have found that approximately 30 million people in England have avoided contracting COVID-19 since the pandemic began. According to their analysis, only about 51.8% of the population has been infected by February 2023, meaning nearly half of England’s residents have not been exposed to the virus directly. While daily cases in the UK recently rose slightly, experts suggest that high vaccination rates and natural immunity offer significant protection against severe disease, reducing concerns of widespread infection among the remaining population.

High Immunity Levels Through Vaccination and Natural Infection

Public health officials estimate that 98% of people in England have antibodies against COVID-19 due to the successful vaccine rollout. This combination of vaccination and natural infection has provided a strong defense against severe illness, particularly as less severe strains like Omicron dominate the current landscape. Dr. Thomas Woolley, a mathematical biologist at Cardiff University, explains that the high rate of vaccination has removed many people from the “susceptible population,” minimizing the chance of a severe outbreak among those who have yet to contract COVID-19.

Omicron’s Mildness and Increased Immunity

With widespread vaccination and the natural immunity obtained through prior infections, England is benefiting from strong levels of population immunity. Microbiologist Professor David Livermore from the University of East Anglia highlights that Omicron’s mild nature, combined with high vaccination rates, has allowed for immunity to build without overwhelming healthcare services. He emphasizes that natural immunity, especially following mild infections, offers longer-lasting protection than vaccination alone. “The more low-risk individuals who become infected, the stronger the collective immunity,” he noted, pointing out that this immunity shift is accelerating England’s transition from pandemic to endemic.

Rising Cases Linked to New Omicron Subvariant BA.2

A recent uptick in COVID-19 cases in the UK is attributed to the emergence of the BA.2 subvariant of Omicron. Known for being more transmissible than its predecessor, BA.2 has quickly become the dominant strain in England. The UK Health Security Agency (UKHSA) reported that BA.2 accounted for over half of all new cases by late February 2023. Although more infectious, BA.2 does not appear to cause more severe illness than the original Omicron strain. Health experts anticipate fluctuations in case rates due to BA.2 but do not expect a significant increase in severe outcomes.

Impact of Freedom Day and Reduced Restrictions

On February 24, England lifted all remaining COVID-19 legal restrictions, including the requirement to self-isolate after a positive test. This decision, referred to as “Freedom Day,” was anticipated to increase transmission rates as more people resume pre-pandemic levels of social interaction. While the government advises people to isolate if they test positive, compliance is voluntary, potentially leading to increased exposure. No10’s scientific advisers warned that easing restrictions could elevate transmission rates by up to 80%, but the impact on hospitalizations and deaths remains minimal, thanks to high immunity levels.

Natural Immunity: A Key Component of Endemic Management

Experts suggest that a lack of natural immunity among uninfected individuals could leave them susceptible to COVID-19, although this susceptibility is mitigated by vaccination. In line with this, Cambridge researchers estimate that 48.2% of England’s population—about 27.3 million people—have not yet had COVID-19. While some scientists argue that natural immunity from infection provides longer-lasting protection than vaccines, they also acknowledge that the vast majority of people unexposed to the virus have likely been vaccinated, providing a substantial level of protection.

Professor Kevin McConway, a statistician at the Open University, stated that the data does not raise significant concerns about susceptibility among the uninfected population, as vaccination has effectively reduced the risk of severe illness and death.

Preparing for Future Variants and NHS Impact

The resilience of the NHS has improved significantly due to the vaccine rollout and immunity buildup. Vaccine boosters provide around 75% protection against hospitalization with the Pfizer vaccine and 90% with Moderna within ten weeks of the dose. Although the number of hospitalized COVID-19 patients rose to 20,000 in January, this figure is nearly half of what it was before vaccines were available. No10 has plans for a spring booster campaign to maintain immunity levels, especially for vulnerable populations, which is expected to help prevent severe illness in any future waves.

However, healthcare professionals warn that even high immunity cannot completely eliminate the risk COVID-19 poses to hospital operations. The presence of COVID-positive patients, even with mild symptoms, can disrupt hospital workflows as they must be separated from non-infected patients, which strains the system and may delay treatment for other conditions.

Maintaining Immunity and Preparing for New Variants

Experts stress the importance of continued vigilance as immunity from vaccinations can wane over time. While Omicron has proven less severe than previous variants, there is always a risk of new mutations that could challenge current immunity levels. Dr. David Strain, a lecturer at the University of Exeter, pointed out the possibility of another surge, especially if booster programs are not maintained.

Studies have shown that individuals who are both vaccinated and previously infected with COVID-19 possess “super immunity” with highly effective antibodies, suggesting that such hybrid immunity could suppress COVID-19 to a manageable, mild infection similar to other respiratory viruses.

Lessons from Other Countries

Countries like Iceland have adopted approaches that prioritize societal resistance to COVID-19, lifting restrictions to allow both vaccinated and unvaccinated individuals to be exposed. Iceland’s health authorities concluded that, despite vaccines’ effectiveness against severe illness, exposure to COVID-19 is essential for transitioning to endemic management. Professor Livermore believes this strategy aligns well with England’s current trajectory, where natural immunity plays a pivotal role in building population resilience.

In summary, nearly half of England’s population has successfully avoided COVID-19 infection, largely due to a combination of effective vaccination and natural immunity. As newer, more transmissible variants emerge, experts advise that maintaining vaccination and embracing mild infection for lower-risk populations could offer a strong pathway out of the pandemic, turning COVID-19 into an endemic, manageable virus.

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